Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046201 | 0.90 | TAS1R3 (0.41) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL9471659 | 0.87 | TAS1R3 (0.40) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL9471199 | 0.79 | TAS1R3 (0.41) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL9044170 | 0.75 | CYP26A1 (0.36) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL9045922 | 0.74 | TAS1R3 (0.35) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL9044667 | 0.73 | ATIC (0.49) | CA1CA2 | |
| SCHEMBL9776064 | 0.73 | TAS1R3 (0.35) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL9046156 | 0.72 | TAS1R3 (0.37) | TAS1R3TAS1R1L3MBTL1ROCK2MAPK14 | |
| SCHEMBL27905011 | 0.69 | TAS1R3 (0.50) | TAS1R3TAS1R1L3MBTL1MAPK14GAA | |
| SCHEMBL27725302 | 0.69 | TAS1R3 (0.50) | TAS1R3TAS1R1L3MBTL1MAPK14GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |