Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26818554 | 0.81 | ADK (0.44) | ADKRAB9ANPC1NOTUMTP53 | |
| SCHEMBL4065247 | 0.78 | ADK (0.44) | ADKNPSR1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4063214 | 0.78 | MAPT (0.47) | ADKNOTUMTP53KDM4ESMN1; SMN2 | |
| SCHEMBL9045520 | 0.76 | EDNRA (0.51) | SMN1; SMN2PTGS2MAPT | |
| SCHEMBL21180006 | 0.75 | MCL1 (0.41) | ADKRAB9ANPC1NOTUMTP53 | |
| SCHEMBL999683 | 0.74 | MAPT (0.50) | ADKRAB9ANPC1TP53NPSR1 | |
| SCHEMBL9045424 | 0.74 | SMN1; SMN2 (0.50) | RAB9ANPC1TP53KDM4ESMN1; SMN2 | |
| SCHEMBL9048672 | 0.74 | CYP1A2 (0.48) | ADKRAB9ANPC1NPSR1KDM4E | |
| SCHEMBL9044194 | 0.73 | PTGS2 (0.38) | RAB9ANPC1KDM4EHPGDNISCH | |
| SCHEMBL9046890 | 0.73 | ALDH1A1 (0.56) | RAB9ANPC1TP53NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |