Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.55 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | DRD5 | P21918 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045178 | 0.79 | DRD3 (0.62) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL9049248 | 0.76 | DRD2 (0.71) | HTR7DRD3DRD2DRD5DRD1 | |
| Hydrochloric Acid SCHEMBL9587355 | 0.75 | DRD2 (0.69) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL11635491 | 0.74 | HTR7 (0.59) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL9369051 | 0.74 | DRD2 (0.63) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL10836050 | 0.74 | HTR7 (0.72) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL21802017 | 0.74 | HTR7 (0.76) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL11630613 | 0.72 | HTR7 (0.73) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL8148701 | 0.72 | DRD2 (0.57) | HTR7DRD3DRD2DRD5DRD1 | |
| SCHEMBL11845590 | 0.72 | ADRA1A (0.58) | HTR7DRD3DRD2DRD5DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | claimed |
| US-5308844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT, ANALGESIC, HYPOTENSIVE AGENT | PIERRE FABRE MEDICAMENT (FR) | 1994-05-03 | — | — | US | disclosed |