Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATIC | P31939 | 3/20 | 0.36 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.36 |
| ▸ | GART | P22102 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | FOLR2 | P14207 | 2/20 | 0.32 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.32 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.32 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | TYMS | P04818 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045922 | 0.90 | TAS1R3 (0.35) | MAPK14ALDH1A1 | |
| SCHEMBL9044079 | 0.87 | MAPK14 (0.36) | MAPK14FOLR2FOLR1SLC46A1ALDH1A1 | |
| SCHEMBL9777813 | 0.86 | ALDH1A1 (0.34) | MAPK1ALDH1A1 | |
| SCHEMBL9045652 | 0.85 | MAPK14 (0.32) | MAPK14MAPK1ALDH1A1KDR | |
| SCHEMBL9046657 | 0.83 | ATIC (0.34) | ATICSHMT1SHMT2GARTMAPK14 | |
| SCHEMBL9044092 | 0.83 | MAPK14 (0.32) | MAPK14MAPK1ALDH1A1KDR | |
| SCHEMBL9047978 | 0.82 | KMT2A (0.36) | — | |
| SCHEMBL9044865 | 0.81 | KMT2A (0.37) | — | |
| SCHEMBL9047324 | 0.81 | KMT2A (0.37) | — | |
| SCHEMBL9045286 | 0.79 | ADORA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |