Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 12/20 | 0.44 |
| ▸ | ATIC | P31939 | 10/20 | 0.41 |
| ▸ | TYMS | P04818 | 3/20 | 0.41 |
| ▸ | SHMT1 | P34896 | 7/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 7/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045220 | 1.00 | GART (0.44) | GARTATICTYMSSHMT1SHMT2 | |
| SCHEMBL9047000 | 0.99 | GART (0.43) | GARTATICTYMSSHMT1SHMT2 | |
| SCHEMBL573199 | 0.82 | DHFR (0.52) | GARTATICTYMSSHMT1SHMT2 | |
| SCHEMBL9044131 | 0.80 | GART (0.50) | GARTATICSHMT1SHMT2KDM4E | |
| SCHEMBL9044516 | 0.80 | ATIC (0.52) | GARTATICSHMT1SHMT2 | |
| SCHEMBL9043298 | 0.80 | FOLR1 (0.48) | GARTATICSHMT1SHMT2KDM4E | |
| SCHEMBL9342476 | 0.80 | ATIC (0.48) | GARTATICTYMSSHMT1SHMT2 | |
| SCHEMBL9045385 | 0.79 | FOLR2 (0.51) | GARTATICSHMT1SHMT2 | |
| SCHEMBL9046824 | 0.78 | ATIC (0.55) | GARTATICTYMSSHMT1SHMT2 | |
| SCHEMBL9048702 | 0.77 | DHFR (0.47) | GARTATICSHMT1SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028608-A | Antineoplastic Agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-07-02 | — | — | US | claimed |
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| US-5028608-A | Antineoplastic Agents | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |