Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047822 | 0.83 | SMN1; SMN2 (0.39) | MAPK1SMN1; SMN2ALDH1A1MAPTHTR1A | |
| SCHEMBL19304367 | 0.81 | ALOX5 (0.46) | KDM1AMAOAL3MBTL1TDP1NFE2L2 | |
| SCHEMBL9046300 | 0.81 | L3MBTL1 (0.39) | L3MBTL1TDP1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9045048 | 0.80 | L3MBTL1 (0.45) | KDM1AMAOAL3MBTL1TDP1NFE2L2 | |
| SCHEMBL9047524 | 0.79 | PTGS2 (0.42) | L3MBTL1SMN1; SMN2MAPTHTR1AADRA1D | |
| SCHEMBL9046868 | 0.78 | LPAR1 (0.42) | L3MBTL1SMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL9047068 | 0.78 | HTR1A (0.36) | SMN1; SMN2ALDH1A1MAPTHTR1AADRA1D | |
| SCHEMBL1239851 | 0.78 | TAAR1 (0.53) | KDM1AMAOAL3MBTL1TDP1NFE2L2 | |
| SCHEMBL20858089 | 0.78 | L3MBTL1 (0.44) | KDM1AMAOAL3MBTL1TDP1NFE2L2 | |
| SCHEMBL7706276 | 0.78 | L3MBTL1 (0.44) | KDM1AMAOAL3MBTL1TDP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |