Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 15/20 | 0.51 |
| ▸ | DRD2 known ✓ | P14416 | 12/20 | 0.51 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.44 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL30908879 | 1.00 | HTR1A (0.51) | HTR1ADRD2HTR2ADRD1DRD3 | |
| Sulfuric Acid SCHEMBL9046410 | 0.77 | HTR1A (0.48) | HTR1ADRD2HTR2A | |
| Sulfuric Acid SCHEMBL30909161 | 0.77 | HTR1A (0.48) | HTR1ADRD2HTR2A | |
| SCHEMBL7465475 | 0.75 | HTR1A (0.57) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7452193 | 0.73 | HTR1A (0.57) | HTR1ADRD2HTR2A | |
| Maleic Acid SCHEMBL30909027 | 0.73 | KDM4A (0.49) | HTR1ADRD2HTR2A | |
| Maleic Acid SCHEMBL9046255 | 0.73 | KDM4A (0.49) | HTR1ADRD2HTR2A | |
| SCHEMBL7456118 | 0.72 | HTR1A (0.49) | HTR1ADRD2HTR2A | |
| SCHEMBL7455854 | 0.71 | HTR1A (0.60) | HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9045432 | 0.70 | HTR1A (0.60) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708102-A1 | 5-HT1F agonists for the treatment of migraine | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |