Maleic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ACE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 BTK CACNA1C CACNA1D CACNA1F CACNA1S CCR5 CPT1B CPT2 DPP4 DRD1 DRD2 EGFR ERBB2 ERBB4 HRH1 HRH3 HTR1A HTR2A HTR2B HTR2C HTR4 JAK1 JAK2 JAK3 MPL MTOR P PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPARG SLC6A2 SLC6A3 SLC6A4 SMO TYK2 pol

The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	SLC6A4 known ✓	P31645	8/20	0.43

▸	HTR1A known ✓	P08908	7/20	0.43

▸	DRD2 known ✓	P14416	4/20	0.42

▸	HTR2A known ✓	P28223	3/20	0.42

▸	KDM4A	O75164	4/20	0.49

▸	KDM4B	O94953	4/20	0.49

▸	KDM5C	P41229	4/20	0.49

▸	KDM5B	Q9UGL1	4/20	0.49

▸	CCR2	P41597	1/20	0.43

▸	HTR7	P34969	4/20	0.42

▸	HTR6	P50406	4/20	0.42

▸	MAPT	P10636	1/20	0.42

▸	BLM	P54132	1/20	0.42

▸	NPSR1	Q6W5P4	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Maleic Acid SCHEMBL9046255	1.00	KDM4A (0.49)	KDM4AKDM4BKDM5CKDM5BSLC6A4
Oxalic Acid SCHEMBL9049150	0.85	SLC6A4 (0.51)	KDM4AKDM4BKDM5CKDM5BSLC6A4
SCHEMBL7455861	0.84	SLC6A4 (0.53)	KDM4AKDM4BKDM5CKDM5BSLC6A4
Oxalic Acid SCHEMBL9048417	0.79	SLC6A4 (0.55)	SLC6A4HTR1ACCR2DRD2HTR7
Oxalic Acid SCHEMBL9046836	0.79	SLC6A4 (0.51)	SLC6A4HTR1ACCR2DRD2HTR7
SCHEMBL7459744	0.77	SLC6A4 (0.54)	SLC6A4HTR1ADRD2HTR7HTR6
Oxalic Acid SCHEMBL9049148	0.76	OPRM1 (0.55)	KDM4AKDM4BKDM5CKDM5BCCR2
SCHEMBL7465697	0.76	KDM4A (0.41)	KDM4AKDM4BKDM5CKDM5BSLC6A4
SCHEMBL7463849	0.76	OPRM1 (0.51)	KDM4AKDM4BKDM5CKDM5BSLC6A4
Oxalic Acid SCHEMBL9046671	0.75	OPRM1 (0.51)	KDM4AKDM4BKDM5CKDM5BCCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20260125645-A1	METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS	VALORISATION HSJ LP (CA)	2026-05-07	—	—	US	disclosed
WO-2024073845-A1	METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS	VALORISATION HSJ, LIMITED PARTNERSHIP (CA)	2024-04-11	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20260125645-A1	METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS	HTR1F, HTR1A, HTR1D	SLC6A4 299/4885HTR1A 2/4885DRD2 691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.