Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.59 |
| ▸ | HTR1B | P28222 | 6/20 | 0.59 |
| ▸ | HTR1A | P08908 | 9/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Avitriptan SCHEMBL147315 | 0.86 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| Avitriptan SCHEMBL29633456 | 0.86 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| Avitriptan SCHEMBL4352074 | 0.86 | HTR1D (0.54) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL9045333 | 0.82 | HTR1D (0.49) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL9047899 | 0.80 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL6765827 | 0.80 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL4349219 | 0.78 | HTR1A (0.49) | HTR1AHTR7KCNH2ADRA1ASLC6A4 | |
| SCHEMBL6363083 | 0.77 | HTR1A (0.49) | HTR1AHTR7KCNH2ADRA1ASLC6A4 | |
| Avitriptan SCHEMBL18396454 | 0.77 | HTR1A (0.57) | HTR1DHTR1BHTR1AHTR2AHTR7 | |
| SCHEMBL6362007 | 0.77 | HTR1D (0.51) | HTR1DHTR1BHTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | claimed |
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | disclosed |