Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | GNRHR | P30968 | 14/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046178 | 0.90 | GNRHR (0.47) | GNRHRP2RX3F2RL3 | |
| SCHEMBL9044284 | 0.81 | AGTR1 (0.43) | GNRHRP2RX3AGTR1 | |
| SCHEMBL7014863 | 0.81 | AGTR1 (0.43) | GNRHRP2RX3AGTR1 | |
| SCHEMBL7010779 | 0.81 | AGTR1 (0.41) | GNRHRP2RX3AGTR1 | |
| SCHEMBL9048490 | 0.80 | AGT (0.47) | GNRHRP2RX3AGTR1 | |
| SCHEMBL9199586 | 0.76 | ACHE (0.52) | CRHBPCRHR2ACHEAGTR1 | |
| SCHEMBL9044702 | 0.70 | AGTR1 (0.46) | AGTR1 | |
| SCHEMBL9045881 | 0.70 | AGTR1 (0.42) | AGTR1 | |
| SCHEMBL9049056 | 0.70 | AGTR1 (0.45) | AGTR1 | |
| SCHEMBL9427847 | 0.69 | ACHE (0.48) | CRHBPCRHR2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443568-B1 | Fused thiophene derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-5284661-A | 4-Oxo-7-(biphenyl-4-yl)thieno(2,3-b)pyridines as antagonist of angiotensin II; hypertensive agents, cardiovascular disorders and strokes | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0443568-A1 | Fused thiophene derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |