Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9052358 | 0.92 | RAB9A (0.43) | RAB9ANPSR1NPC1MAPTLMNA | |
| Fumaric Acid SCHEMBL9052362 | 0.92 | RAB9A (0.43) | RAB9ANPSR1NPC1MAPTLMNA | |
| SCHEMBL8590367 | 0.76 | RAB9A (0.47) | RAB9ANPSR1NPC1MAPTLMNA | |
| SCHEMBL840683 | 0.75 | LMNA (0.50) | RAB9ANPSR1NPC1MAPTLMNA | |
| SCHEMBL8681274 | 0.75 | MAPK1 (0.49) | MAPTSMN1; SMN2ALDH1A1PKML3MBTL1 | |
| SCHEMBL8552983 | 0.73 | GAA (0.45) | RAB9ANPSR1NPC1MAPTLMNA | |
| SCHEMBL21746957 | 0.73 | NFKB1 (0.55) | RAB9ANPSR1NPC1MAPTLMNA | |
| SCHEMBL2221978 | 0.71 | AHR (0.55) | RAB9ANPC1LMNAALDH1A1SYK | |
| SCHEMBL19453365 | 0.69 | RAB9A (0.65) | RAB9ANPSR1NPC1MAPTLMNA | |
| SCHEMBL4174949 | 0.68 | SMN1; SMN2 (0.58) | RAB9ANPSR1NPC1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037513-C | Pyrimidine compound and preparation method of medicinal salt thereof | MITSUI PETROCHEMICAL IND (JP) | 1998-02-25 | — | — | CN | disclosed |
| EP-0379806-B1 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL IND (JP) | 1996-04-10 | — | — | EP | disclosed |
| EP-0612746-A1 | Pyrimidines and their pharmaceutical acceptable salts and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
| CN-1090846-A | The preparation method of pyrimidines and its pharmaceutical salts | MITSUI PETROCHEMICAL IND (JP) | 1994-08-17 | — | — | CN | disclosed |
| US-5264435-A | Treatment of neurological diseases | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5147876-A | Nervous system disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| CN-1045390-A | Pyrimidine compound and preparation method and pharmaceutical use of pharmaceutical salt thereof | MITSUI PETROCHEMICAL IND (JP) | 1990-09-19 | — | — | CN | disclosed |
| EP-0379806-A2 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |