Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 7/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386945 | 0.79 | ALOX5 (0.59) | ALOX5HAO1FFAR1 | |
| SCHEMBL9051127 | 0.77 | ALOX5 (0.45) | ALOX5HAO1HTR2ASLC6A4KCNH2 | |
| SCHEMBL2155272 | 0.75 | CHRM2 (0.56) | HAO1FFAR1CHRM2CHRM1CHRM3 | |
| SCHEMBL11554278 | 0.74 | FFAR1 (0.43) | ALOX5HAO1SLC6A4KCNH2FFAR1 | |
| SCHEMBL9051135 | 0.73 | ALOX5 (0.39) | ALOX5HAO1FFAR1CHRM2CHRM1 | |
| SCHEMBL9050814 | 0.73 | GRM5 (0.47) | HAO1 | |
| SCHEMBL11294787 | 0.73 | FFAR4 (0.43) | PPARGCETPHTR2ASLC6A4KCNH2 | |
| SCHEMBL11392352 | 0.72 | LTA4H (0.48) | HTR2ASLC6A4KCNH2FFAR1FFAR4 | |
| SCHEMBL9047572 | 0.72 | ALOX5 (0.78) | ALOX5 | |
| SCHEMBL11552615 | 0.71 | NAAA (0.42) | ALOX5HAO1SLC6A4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |