Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386945 | 0.84 | ALOX5 (0.59) | ALOX5HAO1MAOB | |
| SCHEMBL920824 | 0.78 | PDE4A (0.46) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9049436 | 0.77 | ALOX5 (0.41) | ALOX5SLC6A4HAO1HTR2AKCNH2 | |
| SCHEMBL2155272 | 0.76 | CHRM2 (0.56) | HAO1EGFRCHRM2CHRM1CHRM3 | |
| SCHEMBL1745148 | 0.75 | MMP2 (0.43) | ALOX5SLC6A4HRH3MAOBAOC3 | |
| SCHEMBL9050814 | 0.74 | GRM5 (0.47) | HAO1 | |
| SCHEMBL11552615 | 0.72 | NAAA (0.42) | ALOX5SLC6A4HRH3HAO1MAOB | |
| SCHEMBL11552305 | 0.72 | FFAR1 (0.42) | ALOX5HRH3EGFRMAOB | |
| SCHEMBL11554278 | 0.72 | FFAR1 (0.43) | ALOX5SLC6A4HRH3HAO1SLC6A2 | |
| SCHEMBL9178583 | 0.72 | ALOX5 (0.52) | ALOX5HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |