Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049046 | 0.86 | EGFR (0.43) | GRM5HAO1 | |
| SCHEMBL9049679 | 0.84 | L3MBTL1 (0.49) | HAO1 | |
| SCHEMBL9050229 | 0.80 | TLR4 (0.42) | GRM5HAO1 | |
| SCHEMBL9386945 | 0.76 | ALOX5 (0.59) | HAO1 | |
| SCHEMBL1011422 | 0.76 | F10 (0.46) | GRM5 | |
| SCHEMBL2155272 | 0.75 | CHRM2 (0.56) | GRM5HAO1 | |
| SCHEMBL9051127 | 0.74 | ALOX5 (0.45) | HAO1 | |
| SCHEMBL9051135 | 0.73 | ALOX5 (0.39) | GRM5HAO1 | |
| SCHEMBL9049436 | 0.73 | ALOX5 (0.41) | HAO1 | |
| SCHEMBL17720580 | 0.73 | MAP4K4 (0.55) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |