Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049287 | 0.90 | LMNA (0.53) | LMNAKDM4ESMN1; SMN2MAPTCA12 | |
| SCHEMBL9116444 | 0.90 | PGR (0.56) | LMNAKDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL9049128 | 0.90 | SIRT2 (0.47) | LMNAKDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL9049557 | 0.89 | LMNA (0.55) | LMNAKDM4ESMN1; SMN2MAPTCA12 | |
| SCHEMBL9047016 | 0.88 | HSD17B10 (0.56) | LMNAKDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL9045528 | 0.87 | PDE4A (0.47) | LMNAKDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL9053739 | 0.85 | KMT2A (0.54) | LMNAKMT2AALDH1A1PGR | |
| SCHEMBL9054120 | 0.85 | SIRT2 (0.52) | KMT2A | |
| SCHEMBL9047335 | 0.85 | KMT2A (0.54) | LMNASMN1; SMN2KMT2APOLB | |
| SCHEMBL8189741 | 0.84 | MAPT (0.60) | LMNAKDM4ESMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734378-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016674-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1995-06-22 | — | — | WO | disclosed |