Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.31 |
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.31 |
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.31 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.31 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.31 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.30 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.30 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.30 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.30 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.30 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.30 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9048779 | 0.92 | HRH4 (0.37) | HRH3HRH4DRD3DRD2DRD4 | |
| SCHEMBL9047634 | 0.91 | DRD3 (0.35) | HRH3DRD3DRD2DRD4L3MBTL1 | |
| SCHEMBL9047746 | 0.86 | L3MBTL1 (0.37) | HRH3L3MBTL1ALDH1A1MEN1KMT2A | |
| Fumaric Acid SCHEMBL9048442 | 0.85 | — | — | |
| Fumaric Acid SCHEMBL9046923 | 0.84 | — | — | |
| Fumaric Acid SCHEMBL9045625 | 0.83 | — | — | |
| Fumaric Acid SCHEMBL9047521 | 0.81 | CYP3A4 (0.36) | KDM4EMEN1KMT2AHTR2BHTR2A | |
| Fumaric Acid SCHEMBL9048088 | 0.80 | — | — | |
| Fumaric Acid SCHEMBL9045597 | 0.79 | — | — | |
| Fumaric Acid SCHEMBL9048324 | 0.79 | GFER (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749966-A1 | 5-HT 3 RECEPTOR AGONIST, NOVEL THIAZOLE DERIVATIVE, AND INTERMEDIATE THEREFOR | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |