Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | DRD1 | P21728 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049140 | 0.89 | HTR1A (0.56) | DRD3DRD1DRD2ADRA1DADRA1A | |
| SCHEMBL9373187 | 0.83 | DRD3 (0.68) | DRD3DRD1DRD2HTR1AHTR2A | |
| SCHEMBL9369214 | 0.83 | DRD3 (0.68) | DRD3DRD1DRD2HTR1AHTR2A | |
| SCHEMBL9047511 | 0.83 | HTR1A (0.54) | DRD3DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL6716162 | 0.80 | DRD3 (0.69) | DRD3DRD1DRD2ADRA1DADRA1A | |
| SCHEMBL9049252 | 0.79 | ADRA1B (0.57) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL9372762 | 0.78 | DRD3 (0.61) | DRD3DRD1DRD2ADRA1DADRA1A | |
| SCHEMBL13711971 | 0.78 | KCNH2 (0.71) | DRD3DRD1DRD2HTR1AHTR2A | |
| SCHEMBL2518183 | 0.77 | ADRA1D (0.71) | DRD3DRD1DRD2ADRA1DADRA1A | |
| SCHEMBL9048565 | 0.77 | KCNH2 (0.53) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | claimed |
| US-5308844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT, ANALGESIC, HYPOTENSIVE AGENT | PIERRE FABRE MEDICAMENT (FR) | 1994-05-03 | — | — | US | disclosed |