Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27302186 | 0.80 | TAAR1 (0.45) | TAAR1ADRA2AADRA2BADRA2CTSHR | |
| SCHEMBL9315687 | 0.80 | CPB2 (0.42) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL18112879 | 0.78 | FPR2 (0.46) | ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL31547895 | 0.78 | TBXAS1 (0.44) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| Hydrochloric Acid SCHEMBL28364020 | 0.77 | TBXAS1 (0.45) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| Bromide SCHEMBL28360500 | 0.77 | TBXAS1 (0.43) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL28201329 | 0.76 | KDM4E (0.39) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL8762157 | 0.75 | PTPRA (0.55) | ADRA2AADRA2BADRA2CSMN1; SMN2CSNK1A1 | |
| SCHEMBL27507351 | 0.75 | FAAH (0.45) | TAAR1 | |
| SCHEMBL4060533 | 0.74 | TBXAS1 (0.39) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513285-B1 | IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA SPA (IT) | 1996-01-24 | — | — | EP | disclosed |
| US-5356920-A | Anticholesterol, antilipemic agent | FARMITALIA CARLO ERBA SRL. (IT) | 1994-10-18 | — | — | US | disclosed |
| EP-0513285-A1 | IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992009582-A1 | IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1992-06-11 | — | — | WO | disclosed |
| US-4985440-A | Hypolipidaemic imidazol-2-yl-derivatives of bicyclic compounds | FARMITALIA CARLO ERBA, S.R.L. (IT) | 1991-01-15 | — | — | US | disclosed |
| EP-0375746-A1 | HYPOLIPIDAEMIC IMIDAZOL-2-YL-DERIVATIVES OF BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1990-07-04 | — | — | EP | disclosed |
| WO-1989008646-A1 | HYPOLIPIDAEMIC IMIDAZOL-2-YL-DERIVATIVES OF BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-09-21 | — | — | WO | disclosed |