Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886917 | 0.87 | MAPT (0.61) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8871046 | 0.84 | MAPT (0.67) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9284194 | 0.79 | MAPT (0.60) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL45506 | 0.79 | MAPT (0.68) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9284192 | 0.79 | MAPT (0.68) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL18785800 | 0.78 | MAPT (0.38) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL1101347 | 0.78 | MAPT (0.68) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL5586004 | 0.78 | RAB9A (0.60) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL4309362 | 0.77 | MAPT (0.71) | MAPTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2839930 | 0.76 | LMNA (0.60) | MAPTSMN1; SMN2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445731-B1 | Azabicyclo and azacyclo oxime and amine cholinergic agents and pharmaceutically acceptable salts thereof | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | claimed |