Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 6/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MGMT | P16455 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8124628 | 0.97 | PNP (0.43) | PNPMPOLTB4RCYP1A2CYP3A4 | |
| SCHEMBL8811713 | 0.77 | TLR7 (0.38) | PNPMPOCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16486743 | 0.73 | PNP (0.39) | PNPCYP1A2CYP3A4CYP2D6MGMT | |
| SCHEMBL16486490 | 0.72 | HRH4 (0.44) | PNPMPOCYP1A2CYP3A4MGMT | |
| SCHEMBL8722636 | 0.71 | DHFR (0.42) | PNPMPOCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9069730 | 0.70 | PNP (0.55) | PNP | |
| SCHEMBL9046769 | 0.70 | LTB4R (0.47) | PNPMPOLTB4RCYP1A2CYP3A4 | |
| SCHEMBL16486348 | 0.69 | ALDH1A1 (0.57) | MPOCYP2D6LMNAPOLBALDH1A1 | |
| SCHEMBL217337 | 0.69 | ADORA1 (0.47) | PNPLTB4RCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL72543 | 0.69 | CDK2 (0.62) | MPOCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708772-A1 | IMIDAZO [4,5-c]PYRIDIN-4-AMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002597-A1 | IMIDAZO[4,5-c]PYRIDIN-4-AMINES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-01-26 | — | — | WO | disclosed |