Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11560765 | 0.82 | MAPT (0.46) | TDP1MAPTKDM4EPDE4DMEN1 | |
| SCHEMBL13607855 | 0.82 | MAPT (0.57) | TDP1MAPTKDM4EPDE4DMEN1 | |
| SCHEMBL9168406 | 0.80 | KDM4E (0.40) | TDP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9624023 | 0.80 | RXFP1 (0.33) | TDP1MAPTKDM4EPDE4DMEN1 | |
| SCHEMBL2214596 | 0.80 | MAPT (0.36) | TDP1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3360767 | 0.78 | HMGCR (0.40) | TDP1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL9052311 | 0.75 | DRD2 (0.45) | TDP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9168647 | 0.74 | PTPN1 (0.39) | TDP1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5444623 | 0.73 | TDP1 (0.50) | TDP1MAPTKDM4EPDE4DALDH1A1 | |
| SCHEMBL3782773 | 0.72 | MAPT (0.62) | TDP1MAPTKDM4EPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |