Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 18/20 | 0.52 |
| ▸ | HTR1A | P08908 | 9/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD5 | P21918 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049355 | 0.88 | HTR7 (0.63) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL8317220 | 0.80 | OPRM1 (0.42) | HTR7HTR1AAHRPDK2DRD2 | |
| SCHEMBL29612136 | 0.77 | HTR7 (0.57) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL1232169 | 0.77 | HTR7 (0.57) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL285431 | 0.77 | HTR2A (0.50) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL5384961 | 0.76 | DRD2 (0.59) | DRD2DRD3 | |
| SCHEMBL23339326 | 0.74 | HTR7 (0.63) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL1764224 | 0.74 | DRD2 (0.60) | DRD2DRD3 | |
| SCHEMBL30641128 | 0.74 | HTR7 (0.63) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL15396975 | 0.74 | HTR7 (0.63) | HTR7HTR1ADRD2DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |