Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | PDE6A | P16499 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056994 | 0.78 | TSHR (0.34) | TSHRCYP2D6TAAR1SMN1; SMN2LMNA | |
| SCHEMBL9057600 | 0.71 | TSHR (0.33) | TSHRSMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL9058015 | 0.70 | FGFR1 (0.43) | TSHRKCNA3 | |
| SCHEMBL9057232 | 0.69 | MAPT (0.36) | TSHRSMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL8811275 | 0.69 | POLB (0.34) | TSHRSMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL5542387 | 0.67 | TSHR (0.45) | TSHRSMN1; SMN2KMT2AMAPTIP6K1 | |
| SCHEMBL28015765 | 0.67 | TSHR (0.39) | TSHRSMN1; SMN2LMNAGLAKMT2A | |
| SCHEMBL9057107 | 0.65 | G6PC1 (0.40) | TAAR1SMN1; SMN2LMNASLC6A3 | |
| SCHEMBL27629572 | 0.64 | CRHBP (0.38) | TSHRKMT2ACRHBPCRHR2 | |
| SCHEMBL8013258 | 0.63 | NR3C2 (0.51) | TSHRTAAR1SMN1; SMN2GLAKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |