SCHEMBL9056994

SCHEMBL9056994

[CH2]c1cccc(N(Cc2ccccc2)c2cc[nH]n2)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.34
CYP2D6 P10635 2/20 0.34
LMNA P02545 3/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
HCAR3 P49019 1/20 0.33
GLA P06280 1/20 0.33
BLM P54132 1/20 0.33
PMP22 Q01453 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
MAOB P27338 1/20 0.33
KMT2A Q03164 4/20 0.33
MAPT P10636 2/20 0.33
KCNA3 P22001 1/20 0.32
MEN1 O00255 1/20 0.32
TAAR1 Q96RJ0 2/20 0.31
CYP1A2 P05177 1/20 0.31
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
PDE6A P16499 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9057969 0.84 NR3C2 (0.35) TSHRCYP2D6LMNASMN1; SMN2HCAR3
SCHEMBL9055863 0.78 TSHR (0.33) TSHRCYP2D6LMNASMN1; SMN2GLA
SCHEMBL8808852 0.77 HRH4 (0.35) SMN1; SMN2HCAR3
SCHEMBL9057232 0.71 MAPT (0.36) TSHRLMNASMN1; SMN2KMT2AMAPT
SCHEMBL9057600 0.70 TSHR (0.33) TSHRLMNASMN1; SMN2PTGDR2KMT2A
SCHEMBL4973167 0.70 HCAR3 (0.50) TSHRCYP2D6LMNASMN1; SMN2HCAR3
SCHEMBL5071266 0.70 PARP1 (0.39) LMNASMN1; SMN2HCAR3
SCHEMBL9058015 0.69 FGFR1 (0.43) TSHRKCNA3NR3C2
SCHEMBL5542387 0.69 TSHR (0.45) TSHRSMN1; SMN2KMT2AMAPTMEN1
SCHEMBL28015765 0.69 TSHR (0.39) TSHRLMNASMN1; SMN2GLAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996010559-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-04-11 WO disclosed