Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950201 | 0.76 | HTT (0.43) | KMT2AALDH1A1HTTKDM1ASMN1; SMN2 | |
| SCHEMBL9058336 | 0.76 | HTT (0.36) | KMT2ALMNAALDH1A1CYP2C19HTT | |
| SCHEMBL9117323 | 0.73 | CA2 (0.44) | — | |
| SCHEMBL8950469 | 0.72 | KMT2A (0.39) | KMT2ALMNAALDH1A1CYP2C19HTT | |
| SCHEMBL2250341 | 0.59 | SIGMAR1 (0.60) | KMT2AALDH1A1HTTKDM4EPOLB | |
| SCHEMBL235080 | 0.58 | KDM4E (0.65) | ALDH1A1GLAKDM4ESMN1; SMN2POLB | |
| SCHEMBL5256238 | 0.57 | HTT (0.69) | KMT2ALMNAALDH1A1CYP2C19HTT | |
| SCHEMBL25262333 | 0.57 | KDM4E (0.90) | KMT2AALDH1A1GAAGLAKDM4E | |
| SCHEMBL11300 | 0.57 | — | — | |
| SCHEMBL4820784 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022099-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| WO-1995019981-A1 | THIENOTHIAZINE SULFONAMIDE DERIVATIVES PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS CARBONIC ANHYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1995-07-27 | — | — | WO | disclosed |