Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9059240 | 1.00 | CTSV (0.56) | CTSVCTSLPDK1PDK2PDK3 | |
| SCHEMBL23771089 | 0.90 | LTA4H (0.60) | CTSVCTSLPDK1PDK2PDK3 | |
| SCHEMBL23771078 | 0.90 | LTA4H (0.60) | CTSVCTSLPDK1PDK2PDK3 | |
| SCHEMBL5954366 | 0.85 | LTA4H (0.63) | MAOBLTA4H | |
| SCHEMBL5954364 | 0.85 | LTA4H (0.63) | MAOBLTA4H | |
| SCHEMBL5297419 | 0.81 | PTGS1 (0.56) | SIRT2MEN1KMT2ALMNAFFAR1 | |
| SCHEMBL19675761 | 0.81 | PDK1 (0.58) | CTSVCTSLPDK1PDK2PDK3 | |
| SCHEMBL6274304 | 0.80 | MTNR1B (0.57) | MEN1KMT2A | |
| SCHEMBL26616883 | 0.80 | MTNR1B (0.57) | MEN1KMT2A | |
| SCHEMBL5011050 | 0.79 | RAB9A (0.67) | KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725790-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | PARKE DAVIS & COMPANY (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1996017861-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |
| WO-1995011917-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | PARKE, DAVIS & COMPANY (US) | 1995-05-04 | — | — | WO | disclosed |