Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318942 | 0.78 | ALDH1A1 (0.62) | KDM4EDBHGAARECQLALDH1A1 | |
| SCHEMBL5569783 | 0.74 | KAT8 (0.57) | KAT8LCKPPARAEGFRRARB | |
| SCHEMBL17586551 | 0.74 | GRIN2D (0.62) | KAT8PPARARARBGRIN2DGRIN2A | |
| SCHEMBL6261628 | 0.73 | RARB (0.51) | KDM4EKAT8PPARARARBBCL2L1 | |
| SCHEMBL551744 | 0.72 | RARB (0.68) | KDM4EKAT8PPARARARBPPARG | |
| SCHEMBL12969257 | 0.72 | KDM4E (0.67) | KDM4EDBHGAARECQLLCK | |
| SCHEMBL17586550 | 0.71 | GRIN2D (0.50) | KAT8LCKPPARARARBGRIN2D | |
| SCHEMBL16899346 | 0.71 | FFAR4 (0.54) | RARBNR1H4 | |
| SCHEMBL5570240 | 0.71 | KAT8 (0.60) | KAT8LCKPPARAEGFRRARB | |
| SCHEMBL11028587 | 0.70 | RARB (0.78) | KAT8PPARARARBPPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |