Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486400 | 0.84 | POLB (0.40) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL29191703 | 0.83 | NOTUM (0.41) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL27008239 | 0.77 | NOS3 (0.50) | MAPTMEN1KMT2ACYP3A4BLM | |
| SCHEMBL9178589 | 0.75 | MAPT (0.51) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6667756 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL13960865 | 0.73 | ALDH1A1 (0.35) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7256137 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7066696 | 0.71 | KDR (0.30) | L3MBTL1HPGD | |
| SCHEMBL7938811 | 0.71 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1394908 | 0.71 | KMT2A (0.39) | ALDH1A1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8311066-A | — | — | None | — | — | JP | disclosed |
| CN-108670970-A | A kind of application of lactam analog compound in drug | 中国海洋大学 | 2018-10-19 | — | — | CN | disclosed |
| CN-108619150-A | A kind of application of lactams alkaloid compound in drug | 中国海洋大学 | 2018-10-09 | — | — | CN | disclosed |
| CN-108619151-A | A kind of application of lactams alkaloid compound in immunoregulation medicament | 中国海洋大学 | 2018-10-09 | — | — | CN | disclosed |
| EP-2201010-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2013-11-06 | — | — | EP | disclosed |
| JP-H08311066-A | NEW 4-OXOQUINOLINECARBOXAMIDE DERIVATIVE OR ITS SALT | YAMANOUCHI PHARMACEUT CO LTD | 1996-11-26 | — | — | JP | disclosed |