Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724293 | 0.83 | GAA (0.43) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL29191703 | 0.79 | NOTUM (0.41) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL5486400 | 0.77 | POLB (0.40) | MAPTLMNAHSP90AA1TSHRKMT2A | |
| SCHEMBL9060888 | 0.75 | ALDH1A1 (0.40) | MAPTLMNAHSP90AA1GAATSHR | |
| SCHEMBL4738113 | 0.75 | MAPT (0.66) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL27884550 | 0.72 | MAPT (0.48) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL1394908 | 0.71 | KMT2A (0.39) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL9181125 | 0.71 | MAPT (0.35) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL14270581 | 0.71 | MAPT (0.64) | MAPTHTTLMNASMN1; SMN2HSP90AA1 | |
| SCHEMBL4764684 | 0.70 | SHMT2 (0.39) | MAPTHTTLMNASMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |