Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Nitrous Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrous Acid SCHEMBL78136 | 0.94 | — | — | |
| Nitrous Acid SCHEMBL184733 | 0.94 | ALDH1A1 (0.75) | ALDH1A1ALOX15TDP1 | |
| Nitrous Acid SCHEMBL9150854 | 0.88 | ALDH1A1 (0.67) | ALDH1A1ALOX15TDP1 | |
| Nitrous Acid SCHEMBL15515206 | 0.88 | — | — | |
| Nitrous Acid SCHEMBL3144393 | 0.88 | ALDH1A1 (0.67) | ALDH1A1ALOX15TDP1 | |
| Nitrous Acid SCHEMBL4551720 | 0.88 | ALDH1A1 (0.67) | ALDH1A1ALOX15TDP1 | |
| Nitrous Acid SCHEMBL4938427 | 0.88 | ALDH1A1 (0.67) | ALDH1A1ALOX15TDP1 | |
| Nitrous Acid SCHEMBL715656 | 0.88 | — | — | |
| Nitrous Acid SCHEMBL10973177 | 0.88 | ALDH1A1 (0.88) | ALDH1A1ALOX15TDP1 | |
| Nitrous Acid SCHEMBL28433610 | 0.88 | ALDH1A1 (0.88) | ALDH1A1ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340780-A | Cubic boron nitride sintered compact and method of preparing the compact | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0255327-B1 | CUBIC BORON NITRIDE MANUFACTURE | DE BEERS INDUSTRIAL DIAMOND DIVISION (PROPRIETARY) LIMITED (ZA) | 1991-06-19 | — | — | EP | claimed |
| EP-0407946-A1 | Cubic boron nitride sintered compact and method of preparing the same | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1991-01-16 | — | — | EP | claimed |
| EP-0255327-A2 | Cubic boron nitride manufacture | DE BEERS INDUSTRIAL DIAMOND DIVISION (PROPRIETARY) LIMITED (ZA) | 1988-02-03 | — | — | EP | claimed |
| US-4287164-A | Process for producing cubic system boron nitride | NATIONAL INSTITUTE FOR RESEARCHES IN INORGANIC MATERIALS (JP) | 1981-09-01 | — | — | US | claimed |
| CN-110573475-B | Sintered body and cutting tool comprising same | 住友电气工业株式会社 | 2022-04-12 | — | — | CN | disclosed |
| CN-110573475-A | Sintered body and cutting tool comprising same | 住友电气工业株式会社 | 2019-12-13 | — | — | CN | disclosed |
| CN-102086373-B | Self-sharpening particles and methods relating thereto | SONG JIANMIN | 2013-06-19 | — | — | CN | disclosed |
| CN-102086373-A | Self-sharpening particles and methods relating thereto | JIANMIN SONG | 2011-06-08 | — | — | CN | disclosed |
| EP-0571914-B1 | Method to work cubic boron nitride article | SUMITOMO ELECTRIC INDUSTRIES (JP) | 1996-08-21 | — | — | EP | disclosed |
| US-5450434-A | Method to work cubic boron nitride article | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1995-09-12 | — | — | US | disclosed |
| US-5340780-A | Cubic boron nitride sintered compact and method of preparing the compact | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0571914-A1 | Method to work cubic boron nitride article | SUMITOMO ELECTRIC INDUSTRIES, LTD (JP) | 1993-12-01 | — | — | EP | disclosed |
| EP-0255327-B1 | CUBIC BORON NITRIDE MANUFACTURE | DE BEERS INDUSTRIAL DIAMOND DIVISION (PROPRIETARY) LIMITED (ZA) | 1991-06-19 | — | — | EP | disclosed |
| EP-0407946-A1 | Cubic boron nitride sintered compact and method of preparing the same | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1991-01-16 | — | — | EP | disclosed |
| US-4883648-A | CRYSTALLIZATION ON SEED MATERIAL, LARGE CRYSTALS | DAVIES GEOFFREY J (ZA) | 1989-11-28 | — | — | US | disclosed |
| EP-0255327-A2 | Cubic boron nitride manufacture | DE BEERS INDUSTRIAL DIAMOND DIVISION (PROPRIETARY) LIMITED (ZA) | 1988-02-03 | — | — | EP | disclosed |
| US-4562163-A | Boron nitride complex and process for its preparation, and process for preparing a light-transmitting dense body of cubic system boron nitride | NATIONAL INSTITUTE FOR RESEARCHES IN INORGANIC MATERIALS (JP) | 1985-12-31 | — | — | US | disclosed |
| US-4409193-A | MAGNESIUM BORON NITRIDE | NATIONAL INSTITUTE FOR RESEARCHES IN INORGANIC MATERIALS (JP) | 1983-10-11 | — | — | US | disclosed |
| US-4287164-A | Process for producing cubic system boron nitride | NATIONAL INSTITUTE FOR RESEARCHES IN INORGANIC MATERIALS (JP) | 1981-09-01 | — | — | US | disclosed |