Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL1663414 | 0.93 | EPHX1 (0.51) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| Ethylene Glycol SCHEMBL906564 | 0.91 | EPHX1 (0.55) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| Ethylene Glycol SCHEMBL28227214 | 0.91 | EPHX1 (0.55) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| Ethylene Glycol SCHEMBL27579683 | 0.91 | EPHX1 (0.55) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| SCHEMBL13460250 | 0.91 | EPHX1 (0.60) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| SCHEMBL16610788 | 0.91 | EPHX1 (0.60) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| SCHEMBL1075940 | 0.91 | EPHX1 (0.60) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| SCHEMBL13460327 | 0.91 | EPHX1 (0.60) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| SCHEMBL5125214 | 0.91 | EPHX1 (0.60) | CYP19A1EPHX1ALDH1A1HPGDLMNA | |
| Bicarbonate SCHEMBL28880176 | 0.90 | EPHX1 (0.53) | CYP19A1EPHX1ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 929 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260047994-A1 | AN ACTIVE COMPOSITION COMPRISING RETINOL | SYMRISE AG (DE) | 2026-02-19 | — | — | US | claimed |
| US-20250352444-A1 | Antimicrobial mixtures | SYMRISE AG (DE) | 2025-11-20 | — | — | US | claimed |
| US-20250325463-A1 | COMPOSITIONS (III) | SYMRISE AG (DE) | 2025-10-23 | — | — | US | claimed |
| EP-4622621-A1 | AN ACTIVE COMPOSITION COMPRISING RETINOL | Symrise AG (DE) | 2025-10-01 | — | — | EP | claimed |
| EP-4525822-A1 | ANTIMICROBIAL MIXTURES | Symrise AG (DE) | 2025-03-26 | — | — | EP | claimed |
| EP-4472606-A1 | COMPOSITIONS (III) | Symrise AG (DE) | 2024-12-11 | — | — | EP | claimed |
| US-20240358611-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2024-10-31 | — | — | US | claimed |
| EP-4429465-A1 | COMPOSITIONS COMPRISING TRPM8 AGONISTIC COOLING AGENTS | Symrise AG (DE) | 2024-09-18 | — | — | EP | claimed |
| US-20240225915-A1 | COMPOSITIONS FOR FIGHTING MALODORS | SYMRISE AG (DE) | 2024-07-11 | — | — | US | claimed |
| EP-4387587-A1 | COMPOSITIONS | Symrise AG (DE) | 2024-06-26 | — | — | EP | claimed |
| WO-2007004740-A1 | VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-01-11 | — | — | WO | claimed |
| WO-2006137556-A1 | FLAVOR AND FRAGRANCE COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-12-28 | — | — | WO | claimed |
| WO-2006130710-A1 | TOPICAL WARMING COMPOSITION | TAKASAGO INTERNATIONAL CORP. (USA) (US) | 2006-12-07 | — | — | WO | claimed |
| US-20060269500-A1 | Topical warming composition | TAKASAGO INTERNATIONAL CORP. (USA) (US) | 2006-11-30 | — | — | US | claimed |
| US-20060217456-A1 | Non-toxic coating composition, methods of use thereof and articles protected from attachment of biofouling organisms | SYMRISE GMBH & CO. KG (DE) | 2006-09-28 | — | — | US | claimed |
| EP-1615974-A1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | Symrise GmbH & Co. KG (DE) | 2006-01-18 | — | — | EP | claimed |
| WO-2004090052-A1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | SYMRISE GMBH & CO. KG (DE) | 2004-10-21 | — | — | WO | claimed |
| EP-1466949-A1 | Non-toxic coating composition, methods of use thereof and articles protected from attachment of biofouling organisms | Symrise GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | claimed |
| EP-1461057-A1 | A TOPICAL ANTI-ITCH FORMULATION AND A PROCESS FOR THE PREPARATION THEREOF | Johnson & Johnson Limited (IN) | 2004-09-29 | — | — | EP | claimed |
| WO-2003047609-A1 | A TOPICAL ANTI-ITCH FORMULATION AND A PROCESS FOR THE PREPARATION THEREOF | JOHNSON & JOHNSON LIMITED (IN) | 2003-06-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060269500-A1 | Topical warming composition | CUTA, NACA, LSM14A | CYP19A1 15/4885EPHX1 1485/4885ALDH1A1 4243/4885 |
| US-20240358611-A1 | COMPOSITIONS | AZI2, NISCH, CIP2A | CYP19A1 619/4885EPHX1 2269/4885ALDH1A1 815/4885 |
| US-20250352444-A1 | Antimicrobial mixtures | LRBA, MGLL, TAS2R50 | CYP19A1 3607/4885EPHX1 3703/4885ALDH1A1 1462/4885 |
| US-20260047994-A1 | AN ACTIVE COMPOSITION COMPRISING RETINOL | RBP4, LRAT, RARB | CYP19A1 1677/4885EPHX1 721/4885ALDH1A1 156/4885 |
| US-20250325463-A1 | COMPOSITIONS (III) | NISCH, TAS1R3, TAS2R3 | CYP19A1 557/4885EPHX1 3052/4885ALDH1A1 1377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.