Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.64 |
| ▸ | CES1 | P23141 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450300 | 0.95 | CES2 (0.58) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL1739996 | 0.89 | CES2 (0.60) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL15234991 | 0.88 | CES2 (0.48) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL9578922 | 0.86 | MAPT (0.69) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL11430643 | 0.85 | PARP10 (0.59) | MAPTALDH1A1PARP10 | |
| SCHEMBL6278770 | 0.85 | KDM4E (0.58) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL7988181 | 0.84 | CES2 (0.53) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL7988180 | 0.84 | CES2 (0.53) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL21636224 | 0.84 | L3MBTL1 (0.54) | MAPTALDH1A1HTTPARP10 | |
| SCHEMBL27654000 | 0.84 | MAPT (0.62) | CES2CES1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3619214-B1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2024-11-06 | — | — | EP | claimed |
| EP-3630776-B1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2023-05-17 | — | — | EP | claimed |
| US-11339174-B2 | γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-05-24 | — | — | US | claimed |
| US-20210198273-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-01 | — | — | US | claimed |
| US-10941155-B2 | Furo[2,3-b]pyran-2-one compounds and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-03-09 | — | — | US | claimed |
| US-20200165263-A1 | FURO[2,3-b]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-05-28 | — | — | US | claimed |
| EP-3630776-A1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2020-04-08 | — | — | EP | claimed |
| EP-3619214-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2020-03-11 | — | — | EP | claimed |
| WO-2018220647-A1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-12-06 | — | — | WO | claimed |
| WO-2018203346-A1 | γ-SPIROKETAL- γ –LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-11-08 | — | — | WO | claimed |
| EP-3619214-B1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2024-11-06 | — | — | EP | disclosed |
| WO-2024148274-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |
| WO-2024148274-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |
| EP-3630776-B1 | FURO[2,3-B]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2023-05-17 | — | — | EP | disclosed |
| WO-2023071855-A1 | HYDRAZONE-BASED ZN (II) COORDINATION COMPLEX PHOTOCHROMIC MATERIAL, PREPARATION AND USE THEREOF | 南京邮电大学 | 2023-05-04 | — | — | WO | disclosed |
| WO-1994027964-A1 | 3-(INDOL-3-YL) PROPENOIC ACID DERIVATIVES AND AS NMDA ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| US-4542220-A | Preparation of derivatives of dichloroacetic acid esters | STAMICARBON B.V., LICENSING SUBSIDIARY OF DSM (NL) | 1985-09-17 | — | — | US | disclosed |
| EP-0075355-B1 | THE PREPARATION OF DERIVATIVES OF DICHLOROACETIC ACID ESTERS | STAMICARBON B.V. (NL) | 1985-08-28 | — | — | EP | disclosed |
| EP-0075355-A1 | The preparation of derivatives of dichloroacetic acid esters | STAMICARBON B.V. (NL) | 1983-03-30 | — | — | EP | disclosed |
| US-4229274-A | PHOTOINITIATOR, PHOTOSENSITIZER, QUENCHER, AND COMPOUNDS CONTAINING ACRYLYLOXY GROUPS | PPG INDUSTRIES, INC. (US) | 1980-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10941155-B2 | Furo[2,3-b]pyran-2-one compounds and process for preparation thereof | KMO, ALDOA, AKR1C2 | CES2 3141/4885CES1 915/4885HDAC3 1508/4885 |
| US-11339174-B2 | γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof | HSD17B7, PKD1, CYP17A1 | CES2 3614/4885CES1 895/4885HDAC3 612/4885 |
| US-20200165263-A1 | FURO[2,3-b]PYRAN-2-ONE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF | KMO, ALDOA, AKR1C2 | CES2 3141/4885CES1 915/4885HDAC3 1508/4885 |
| US-20210198273-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | HSD17B7, PKD1, CYP17A1 | CES2 3608/4885CES1 883/4885HDAC3 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.