Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12817186 | 0.74 | PTPN1 (0.41) | LMNANPSR1P2RX7PTPN1HPGD | |
| Hydrochloric Acid SCHEMBL2116834 | 0.69 | NPSR1 (0.38) | LMNANPSR1P2RX7PTPN1HPGD | |
| Hydrochloric Acid SCHEMBL2116546 | 0.69 | NPSR1 (0.38) | LMNANPSR1P2RX7PTPN1HPGD | |
| Hydrochloric Acid SCHEMBL7929379 | 0.68 | LMNA (0.38) | LMNANPSR1P2RX7PTPN1HPGD | |
| Hydrochloric Acid SCHEMBL4588710 | 0.68 | PTPN1 (0.38) | LMNANPSR1P2RX7PTPN1HPGD | |
| Hydrochloric Acid SCHEMBL17823015 | 0.67 | HDAC8 (0.37) | LMNANPSR1P2RX7PTPN1HPGD | |
| SCHEMBL12218523 | 0.61 | NPSR1 (0.96) | LMNANPSR1PTPN1HPGDGAA | |
| SCHEMBL1946708 | 0.60 | NPSR1 (0.72) | LMNANPSR1PTPN1HPGDKMT2A | |
| SCHEMBL24618011 | 0.58 | HDAC8 (0.61) | LMNANPSR1PTPN1HPGDKMT2A | |
| SCHEMBL6917808 | 0.58 | HDAC8 (0.61) | LMNANPSR1PTPN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5539056-A | POLYPROPYLENE BLEND OF HIGH AND LOW MOLECULAR WEIGHT POLYMERS FOR HIGH STRENGTH FLEXIBLE HOSES, TUBES, AUTOMOBILE BUMPERS, GASKETS OR MEDICAL DEVICES | EXXON CHEMICAL PATENTS INC. (US) | 1996-07-23 | — | — | US | disclosed |