Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.43 |
| ▸ | MME | P08473 | 7/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10920363 | 1.00 | ACE (0.43) | ACEMMECPB2ALDH1A1LTA4H | |
| SCHEMBL9067765 | 0.86 | ALDH1A1 (0.54) | MMEALDH1A1 | |
| SCHEMBL489084 | 0.81 | CPB2 (0.51) | ACEMMECPB2ALDH1A1CPA1 | |
| SCHEMBL489085 | 0.81 | CPB2 (0.51) | ACEMMECPB2ALDH1A1CPA1 | |
| SCHEMBL9068564 | 0.77 | ALDH1A1 (0.44) | ACEMMECPB2ALDH1A1CPA1 | |
| SCHEMBL9068715 | 0.77 | MME (0.67) | ACEMMELTA4H | |
| SCHEMBL9674217 | 0.77 | MME (0.67) | ACEMMELTA4H | |
| SCHEMBL9068638 | 0.76 | MME (0.58) | ACEMMECPA1ACE2 | |
| SCHEMBL9068808 | 0.76 | MMP2 (0.65) | ACEMMECPA1ACE2 | |
| SCHEMBL9069306 | 0.75 | ECE1 (0.43) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0067429-B1 | INHIBITORS OF MAMMALIAN COLLAGENASE | E.R. Squibb & Sons, Inc. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4424354-A | MERCAPTOALKANOYL DERIVATIVES OF PEPTIDES | E. R. SQUIBB & SONS, INC. (US) | 1984-01-03 | — | — | US | disclosed |
| US-4382081-A | ANTIARRTHRITIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1983-05-03 | — | — | US | disclosed |