Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9230716 | 0.97 | METAP1 (0.33) | METAP1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9166044 | 0.95 | METAP1 (0.32) | METAP1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9068643 | 0.77 | PGR (0.36) | METAP1 | |
| SCHEMBL8917219 | 0.76 | METAP1 (0.41) | METAP1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9171690 | 0.75 | TDP2 (0.36) | — | |
| Hydrochloric Acid SCHEMBL5346994 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL9165414 | 0.72 | PGR (0.36) | METAP1 | |
| Hydrochloric Acid SCHEMBL9163417 | 0.72 | PNMT (0.37) | — | |
| Hydrochloric Acid SCHEMBL9231644 | 0.72 | MEN1 (0.33) | METAP1MEN1MAPTKMT2A | |
| SCHEMBL28025369 | 0.72 | METAP1 (0.37) | METAP1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571880-A | CATALYSTS FOR POLYMERIZATION OF OLEFINS ESPECIALLY TO OBTAIN SYNDIOTACTIC POLYMERS | PHILLIPS PETROLEUM COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| US-5420320-A | Method for preparing cyclopentadienyl-type ligands and metallocene compounds | PHILLIPS PETROLEUM COMPANY (US) | 1995-05-30 | — | — | US | disclosed |