Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2672468 | 0.81 | PNMT (0.44) | PNMTPGRNPC1RAB9ASIGMAR1 | |
| SCHEMBL27866853 | 0.80 | PNMT (0.43) | PNMTPGRNPC1RAB9ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL5359306 | 0.77 | PGR (0.41) | PNMTPGRNPC1RAB9ACHRM2 | |
| SCHEMBL3425445 | 0.77 | PNMT (0.43) | PNMTPGRNPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL29238201 | 0.77 | GPR3 (0.35) | PNMTNPC1RAB9ASIGMAR1DRD2 | |
| SCHEMBL6759460 | 0.76 | PNMT (0.42) | PNMTPGRNPC1RAB9AALDH1A1 | |
| SCHEMBL6760396 | 0.76 | PNMT (0.42) | PNMTPGRNPC1RAB9AALDH1A1 | |
| SCHEMBL167384 | 0.76 | PNMT (0.42) | PNMTPGRNPC1RAB9AALDH1A1 | |
| SCHEMBL6758782 | 0.76 | PNMT (0.42) | PNMTPGRNPC1RAB9AALDH1A1 | |
| SCHEMBL235556 | 0.76 | PNMT (0.42) | PNMTPGRNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571880-A | CATALYSTS FOR POLYMERIZATION OF OLEFINS ESPECIALLY TO OBTAIN SYNDIOTACTIC POLYMERS | PHILLIPS PETROLEUM COMPANY (US) | 1996-11-05 | — | — | US | disclosed |