Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KDM5C | P41229 | 3/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988079 | 0.82 | DNM1 (0.44) | PLA2G2CLMNAPOLBKDM4EPLA2G10 | |
| SCHEMBL13850710 | 0.82 | CA12 (0.43) | PLA2G2CLMNAPOLBKDM4EPLA2G10 | |
| SCHEMBL12220635 | 0.82 | PLA2G10 (0.50) | PLA2G2CPHF8KDM2AKDM4EKDM5C | |
| SCHEMBL19520081 | 0.81 | HDAC3 (0.50) | PLA2G2CLMNAPOLBPLA2G10CA12 | |
| SCHEMBL13458546 | 0.80 | SMN1; SMN2 (0.53) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL799655 | 0.80 | SMN1; SMN2 (0.53) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL20987985 | 0.78 | PHF8 (0.54) | PLA2G2CLMNAPOLBPHF8KDM2A | |
| SCHEMBL12655871 | 0.78 | GNPAT (0.56) | POLBPHF8KDM2AKDM4EKDM5C | |
| SCHEMBL7158525 | 0.78 | PHF8 (0.43) | PLA2G2CLMNAPHF8KDM2AKDM4E | |
| SCHEMBL8367141 | 0.77 | DNM1 (0.48) | PLA2G2CLMNAPOLBKDM4ECA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
| US-10246478-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| US-8293933-B2 | Method of producing substance immobilizing carrier | DAI NIPPON PRINTING CO., LTD. (JP) | 2012-10-23 | — | — | US | disclosed |
| US-20110257028-A1 | Method for selectively binding a substrate to sorbents by way of at least bivalent bonds | INSTRACTION GMBH (DE) | 2011-10-20 | — | — | US | disclosed |
| US-20110257028-A1 | Method for selectively binding a substrate to sorbents by way of at least bivalent bonds | INSTRACTION GMBH (DE) | 2011-10-20 | — | — | US | disclosed |
| US-20090149667-A1 | METHOD OF PRODUCING SUBSTANCE IMMOBILIZING CARRIER | DAI NIPPON PRINTING CO., LTD. (JP) | 2009-06-11 | — | — | US | disclosed |
| US-5484771-A | RIBONUCLEOTIDE REDUCTASE INHIBITORS | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1996-01-16 | — | — | US | disclosed |
| EP-0461546-B1 | Antiherpes peptide derivatives having a 1,4-dioxo-C4 N-terminus | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1995-03-22 | — | — | EP | disclosed |
| EP-0461546-A2 | Antiherpes peptide derivatives having a 1,4-dioxo-C4 N-terminus | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1991-12-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257028-A1 | Method for selectively binding a substrate to sorbents by way of at least bivalent bonds | SPR, ABCG2, SHBG | PLA2G2C 2430/4885LMNA 3358/4885POLB 1246/4885 |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | PLA2G2C 3217/4885LMNA 742/4885POLB 801/4885 |
| US-10246478-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | PLA2G2C 3217/4885LMNA 742/4885POLB 801/4885 |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | PLA2G2C 3217/4885LMNA 742/4885POLB 801/4885 |
| US-20090149667-A1 | METHOD OF PRODUCING SUBSTANCE IMMOBILIZING CARRIER | HCAR2, CA14, HCAR1 | PLA2G2C 1537/4885LMNA 3112/4885POLB 4151/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | PLA2G2C 3217/4885LMNA 742/4885POLB 801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.