Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | IDH2 | P48735 | 3/20 | 0.58 |
| ▸ | KIF11 | P52732 | 3/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544808 | 0.89 | IDH2 (0.77) | RAPGEF4IDH2APPMAPTMAPK1 | |
| SCHEMBL394991 | 0.88 | KIF11 (0.70) | RAPGEF4NPSR1RAB9AHTTMEN1 | |
| SCHEMBL8971887 | 0.87 | APP (0.69) | RAPGEF4NPSR1RAB9AHTTIDH2 | |
| SCHEMBL1921482 | 0.84 | KIF11 (0.70) | RAPGEF4NPSR1RAB9AIDH2KIF11 | |
| SCHEMBL11114688 | 0.83 | MAPT (0.62) | RAPGEF4RAB9AHTTMEN1KMT2A | |
| SCHEMBL7347670 | 0.82 | IDH2 (0.77) | RAPGEF4RAB9AHTTMEN1KMT2A | |
| SCHEMBL30575363 | 0.82 | IDH2 (0.77) | RAPGEF4RAB9AHTTMEN1KMT2A | |
| SCHEMBL148048 | 0.82 | NFE2L2 (0.55) | RAPGEF4RAB9AHTTMEN1KMT2A | |
| SCHEMBL6728267 | 0.82 | MEN1 (0.63) | RAPGEF4NPSR1RAB9AHTTMEN1 | |
| SCHEMBL22065211 | 0.82 | MAPT (0.72) | NPSR1RAB9AHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246028-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-22 | — | — | EP | disclosed |
| EP-0475676-B1 | Electrophotographic member | HITACHI CHEMICAL CO LTD (JP) | 1996-04-03 | — | — | EP | disclosed |