Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458275 | 0.87 | PDE4B (0.63) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL2649911 | 0.84 | ALDH1A1 (0.57) | HPGDMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL2665979 | 0.80 | GCGR (0.51) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL2665957 | 0.72 | MAPT (0.55) | HPGDMAPTALDH1A1HTTKDM4E | |
| SCHEMBL7929684 | 0.71 | PDE4B (0.55) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL21260713 | 0.71 | PDE4B (0.52) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL21247126 | 0.70 | RAB9A (0.65) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL21333308 | 0.70 | MAPT (0.59) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL4227925 | 0.69 | MAPT (0.48) | PDE4BPDE4DHPGDMAPTALDH1A1 | |
| SCHEMBL5371517 | 0.69 | ALDH1A1 (0.56) | PDE4BPDE4DHPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024066-A2 | METHOD OF TREATING DIABETES AND RELATED CONDITIONS | MERCK & CO., INC. (US) | 2004-03-25 | — | — | WO | disclosed |