2-Pyrrolidone

2-Pyrrolidone

SCHEMBL9075700

C=C(C)C(=O)OCCC([Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C)([Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C)[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C.O=C1CCCN1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.35
THRB P10828 1/20 0.32
TSHR P16473 2/20 0.31
FKBP5 Q13451 1/20 0.31
CRBN Q96SW2 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1554939 0.83 THRB (0.43) THRBTSHRALDH1A1
2-Pyrrolidone SCHEMBL17241782 0.77 OR51E2 (0.46) OR51E2THRBTSHRFKBP5CRBN
2-Pyrrolidone SCHEMBL28304483 0.77 OR51E2 (0.46) OR51E2THRBTSHRFKBP5CRBN
2-Pyrrolidone SCHEMBL8133376 0.76 OR51E2 (0.47) OR51E2THRBTSHRFKBP5CRBN
2-Pyrrolidone SCHEMBL8168482 0.75 TSHR (0.55) OR51E2THRBTSHRFKBP5CRBN
2-Pyrrolidone SCHEMBL867329 0.74 OR51E2 (0.42) OR51E2THRBTSHRFKBP5CRBN
2-Pyrrolidone SCHEMBL28270057 0.73 OR51E2 (0.44) OR51E2THRBTSHRFKBP5CRBN
2-Pyrrolidone SCHEMBL28734991 0.73 TSHR (0.65) OR51E2THRBTSHRFKBP5CRBN
Methacrylic Acid SCHEMBL28736810 0.72 OR51E2 (0.43) OR51E2THRBTSHRFKBP5CRBN
Caprolactam SCHEMBL6747086 0.72 FKBP5 (0.46) OR51E2THRBTSHRFKBP5CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0692100-A1 IMPROVED ITACONATE COPOLYMERIC COMPOSITIONS FOR CONTACT LENSES POLYMER TECHNOLOGY CORPORATION (US) 1996-01-17 EP disclosed