Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | C1S | P09871 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13387644 | 0.80 | ALOX5 (0.43) | ALOX5PTGS1PTGS2ABL1C1S | |
| SCHEMBL7721910 | 0.80 | ALOX5 (0.61) | ALOX5PTGS1PTGS2ABL1MGLL | |
| SCHEMBL907934 | 0.80 | ABL1 (0.64) | ALOX5PTGS1PTGS2ABL1MAPT | |
| SCHEMBL7719095 | 0.80 | ALOX5 (0.61) | ALOX5PTGS1PTGS2ABL1C1S | |
| SCHEMBL11368286 | 0.80 | ALOX5 (0.61) | ALOX5PTGS1PTGS2ABL1MAPT | |
| Bw-755C SCHEMBL30088397 | 0.80 | ALOX5 (1.00) | ALOX5PTGS1PTGS2ABL1NOTUM | |
| Bw-755C SCHEMBL2573191 | 0.80 | ALOX5 (1.00) | ALOX5PTGS1PTGS2ABL1NOTUM | |
| SCHEMBL7717944 | 0.79 | ABL1 (0.57) | ALOX5PTGS1PTGS2ABL1MAPT | |
| Bw-755C SCHEMBL1040411 | 0.78 | ALOX5 (0.97) | ALOX5PTGS1PTGS2ABL1NOTUM | |
| SCHEMBL7719905 | 0.78 | ALOX5 (0.58) | ALOX5PTGS1PTGS2ABL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003862-A1 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases | MERCK SHARP & DOHME LIMITED (GB) | 2011-01-06 | — | — | US | claimed |
| EP-1987007-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LTD. (GB) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093829-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-23 | — | — | WO | claimed |
| US-6387136-B1 | OXIDATION COLOR DYES AND COUPLER | L'OREAL S.A. (FR) | 2002-05-14 | — | — | US | claimed |
| EP-0974337-B1 | Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit | OREAL (FR) | 2001-03-21 | — | — | EP | claimed |
| EP-0974337-A1 | Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit | L'OREAL (FR) | 2000-01-26 | — | — | EP | claimed |
| US-4451479-A | ANTIINFLAMMATORY | AMERICAN CYANAMID COMPANY (US) | 1984-05-29 | — | — | US | claimed |
| US-20110003862-A1 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases | MERCK SHARP & DOHME LIMITED (GB) | 2011-01-06 | — | — | US | disclosed |
| EP-1987007-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LTD. (GB) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093829-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-23 | — | — | WO | disclosed |
| US-6387136-B1 | OXIDATION COLOR DYES AND COUPLER | L'OREAL S.A. (FR) | 2002-05-14 | — | — | US | disclosed |
| EP-0974337-B1 | Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit | OREAL (FR) | 2001-03-21 | — | — | EP | disclosed |
| EP-0974337-A1 | Keratinous fibre dyeing compositions containing 3-amino pyrazoline derivatives as coupling agents, process for dyeing and dyeing kit | L'OREAL (FR) | 2000-01-26 | — | — | EP | disclosed |
| US-4451479-A | ANTIINFLAMMATORY | AMERICAN CYANAMID COMPANY (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0070376-A1 | Heterocyclic substituted-amino-pyrazolines | AMERICAN CYANAMID COMPANY (US) | 1983-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003862-A1 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases | DAO, DDO, MAOA | ALOX5 1140/4885PTGS1 1991/4885PTGS2 2364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.