Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 4/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090578 | 0.79 | MAPK14 (0.42) | GABRA2GABRB2MAPK14MAPK13MAPK12 | |
| SCHEMBL9277485 | 0.78 | MAPT (0.37) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL7090574 | 0.72 | ALOX5 (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7090577 | 0.71 | MAPK14 (0.35) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7088083 | 0.65 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7090794 | 0.64 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9006002 | 0.62 | HMGCR (0.41) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9791608 | 0.62 | FAAH (0.45) | MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7085315 | 0.62 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9791607 | 0.59 | FAAH (0.37) | GABRA2GABRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |