Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 2/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081966 | 0.78 | GABRA2 (0.35) | MAPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7090574 | 0.77 | ALOX5 (0.37) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL7090577 | 0.77 | MAPK14 (0.35) | MAPK14ALOX5MAPK13GCGRMAPK12 | |
| SCHEMBL7090578 | 0.72 | MAPK14 (0.42) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL7088083 | 0.67 | MAPK14 (0.43) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL9791608 | 0.67 | FAAH (0.45) | MAPTPOLBNPSR1KDM4EALDH1A1 | |
| SCHEMBL7090794 | 0.66 | MAPK14 (0.43) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL9006002 | 0.64 | HMGCR (0.41) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7085315 | 0.64 | MAPK14 (0.42) | MAPK14MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL9791607 | 0.62 | FAAH (0.37) | MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |