Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylethyl Alcohol SCHEMBL7240959 | 0.88 | TDP1 (0.94) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL9354513 | 0.85 | TDP1 (0.89) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL11450063 | 0.85 | TDP1 (1.00) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL1867158 | 0.85 | TDP1 (1.00) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL1838 | 0.85 | — | — | |
| Phenylethyl Alcohol SCHEMBL28820852 | 0.85 | TDP1 (1.00) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL8968173 | 0.85 | TDP1 (1.00) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL27927126 | 0.85 | TDP1 (1.00) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL5967453 | 0.83 | TDP1 (0.94) | TDP1CA2TSHRCYP4F2CYP4A11 | |
| Phenylethyl Alcohol SCHEMBL5946545 | 0.83 | TDP1 (0.94) | TDP1CA2TSHRCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160008322-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP (CA) | 2016-01-14 | — | — | US | disclosed |
| US-20140314685-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2014-10-23 | — | — | US | disclosed |
| US-20130171077-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2013-07-04 | — | — | US | disclosed |
| US-8163938-B2 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2012-04-24 | — | — | US | disclosed |
| EP-1666459-B1 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP (CA) | 2011-10-19 | — | — | EP | disclosed |
| US-8008342-B2 | Ion channel modulating compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2011-08-30 | — | — | US | disclosed |
| US-20110207730-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2011-08-25 | — | — | US | disclosed |
| EP-2298735-A1 | Aminocyclohexyl ether compounds and uses thereof | Cardiome Pharma Corp. (CA) | 2011-03-23 | — | — | EP | disclosed |
| US-7875611-B2 | (+)-trans-[2-(4-morpholinyl)-1-[2-(2-naphthoxy)ethoxy)]; (1R,2R)/(1S,2S)-2-[1,4-dioxa-7-azaspiro[4.4]non-7-yl]-1-(1-naphthenethoxy)cyclohexanecyclohexane; treatment of arrhythmia and the production of analgesia and local anesthesia | CARDIOME PHARMA CORP. (CA) | 2011-01-25 | — | — | US | disclosed |
| US-20110004006-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2011-01-06 | — | — | US | disclosed |
| US-20060189677-A1 | Treatment of arrhythmia and the production of analgesia and local anesthesia by administering 1-[2-(3,4-dimethoxyphenyl)ethoxy]-2-(3-hydroxy-1-pyrrolidinyl)cyclohexane or a salt | CARDIOME PHARMA CORP. (CA) | 2006-08-24 | — | — | US | disclosed |
| EP-1666459-A2 | Aminocyclohexyl ether compounds and uses thereof | Cardiome Pharma Corp. (CA) | 2006-06-07 | — | — | EP | disclosed |
| US-7057053-B2 | for treatment of arrhythmia and the production of analgesia and local anesthesia | CARDIOME PHARMA CORP. (CA) | 2006-06-06 | — | — | US | disclosed |
| EP-1560812-B1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP (CA) | 2006-05-10 | — | — | EP | disclosed |
| US-20050209307-A1 | Cardiovascular disorders; antiarrhythmia agents as result od analgesics, anesthetics | CARDIOME PHARMA CORP. (CA) | 2005-09-22 | — | — | US | disclosed |
| US-20050192208-A2 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2005-09-01 | — | — | US | disclosed |
| US-20050020481-A1 | Ion channel modulating compounds and uses thereof | BAIN ALLAN I (CA) | 2005-01-27 | — | — | US | disclosed |
| EP-1422217-A2 | Aminocyclohexyl ether compounds and uses thereof | Cardiome Pharma Corp. (CA) | 2004-05-26 | — | — | EP | disclosed |
| EP-1087934-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | Nortran Pharmaceuticals Inc. (CA) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999050225-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | NORTRAN PHARMACEUTICALS INC. (CA) | 1999-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110004006-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | KCNH2, KCNC1, KCNH3 | TDP1 1872/4885CA2 407/4885TSHR 3782/4885 |
| US-20130171077-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | TDP1 4354/4885CA2 166/4885TSHR 2898/4885 |
| US-20110207730-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | TDP1 4354/4885CA2 166/4885TSHR 2898/4885 |
| US-20050020481-A1 | Ion channel modulating compounds and uses thereof | TRPV1, TRPA1, KCNN2 | TDP1 4354/4885CA2 166/4885TSHR 2898/4885 |
| US-20050209307-A1 | Cardiovascular disorders; antiarrhythmia agents as result od analgesics, anesthetics | KCNH1, TRPV1, KCNH2 | TDP1 1189/4885CA2 221/4885TSHR 3313/4885 |
| US-20160008322-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | TDP1 4354/4885CA2 166/4885TSHR 2898/4885 |
| US-20140314685-A1 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | TDP1 4354/4885CA2 166/4885TSHR 2898/4885 |
| US-20060189677-A1 | Treatment of arrhythmia and the production of analgesia and local anesthesia by administering 1-[2-(3,4-dimethoxyphenyl)ethoxy]-2-(3-hydroxy-1-pyrrolidinyl)cyclohexane or a salt | KCNN2, KCNN3, KCNN1 | TDP1 2955/4885CA2 124/4885TSHR 2369/4885 |
| US-20050192208-A2 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | TRPV1, TRPA1, KCNN2 | TDP1 3829/4885CA2 169/4885TSHR 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.