Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 6/20 | 0.37 |
| ▸ | KDM6B | O15054 | 4/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | APOB | P04114 | 3/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xenalipin SCHEMBL9094220 | 0.84 | MTTP (0.40) | MTTPKDM6BKDM4CKDM1AFPR2 | |
| SCHEMBL6967303 | 0.78 | TBXA2R (0.40) | KDM1AADRB3 | |
| Xenalipin SCHEMBL9094027 | 0.73 | MTTP (0.42) | MTTPFPR2PPARG | |
| SCHEMBL6973361 | 0.70 | ADRB2 (0.41) | KDM1A | |
| SCHEMBL9093528 | 0.70 | DRD2 (0.34) | MTTPAPOBADRB3ADRA2BDRD1 | |
| SCHEMBL6974470 | 0.68 | ADRB2 (0.42) | KDM1ADRD1 | |
| Xenalipin SCHEMBL133087 | 0.67 | CYP2C8 (0.58) | MTTPFPR2APOB | |
| Xenalipin SCHEMBL29881739 | 0.67 | CYP2C8 (0.58) | MTTPFPR2APOB | |
| SCHEMBL8472080 | 0.67 | KDM1A (0.47) | KDM1ASIGMAR1 | |
| SCHEMBL8211362 | 0.67 | MTTP (0.54) | MTTPAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040640-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |