Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 11/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | MTTP | P55157 | 3/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.31 |
| ▸ | DRD1 | P21728 | 3/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | APOB | P04114 | 2/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | DRD5 | P21918 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094218 | 0.84 | LTB4R (0.38) | P2RY14LTB4RLTB4R2MTTPDHODH | |
| SCHEMBL9094018 | 0.75 | MTNR1B (0.38) | DRD2P2RY14MTTPSCN9A | |
| Xenalipin SCHEMBL9093534 | 0.70 | MTTP (0.37) | P2RY14MTTPTMEM97DRD1SIGMAR1 | |
| SCHEMBL6967300 | 0.68 | — | — | |
| SCHEMBL593309 | 0.67 | CYP2C8 (0.51) | DHODH | |
| SCHEMBL27362184 | 0.62 | FOLH1 (0.51) | DHODH | |
| SCHEMBL6497035 | 0.62 | BACE1 (0.47) | DHODH | |
| SCHEMBL23354270 | 0.60 | IL2 (0.49) | DHODH | |
| SCHEMBL10058719 | 0.60 | RXRA (0.51) | P2RY14TMEM97DRD1SIGMAR1ADRB3 | |
| SCHEMBL28296124 | 0.56 | GAA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040640-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |