Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131163 | 0.88 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL18359320 | 0.86 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL12725093 | 0.84 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL7515726 | 0.82 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL28546945 | 0.81 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL18131247 | 0.81 | L3MBTL1 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL1559275 | 0.80 | L3MBTL1 (0.63) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL326566 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL18131893 | 0.79 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL18131196 | 0.79 | L3MBTL1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |
| US-8426588-B2 | Phenylalanine derivatives | AJINOMOTO CO, INC. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-20120253041-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2012-10-04 | — | — | US | disclosed |
| US-8222405-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20110065918-A1 | NEW PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2011-03-17 | — | — | US | disclosed |
| EP-1288205-B1 | NOVEL PHENYLALANINE DERIVATIVES | AJINOMOTO KK (JP) | 2011-02-02 | — | — | EP | disclosed |
| US-7872125-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2011-01-18 | — | — | US | disclosed |
| EP-1477482-B1 | NOVEL PHENYLALANINE DERIVATIVE | AJINOMOTO KK (JP) | 2010-04-14 | — | — | EP | disclosed |
| US-7605165-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2009-10-20 | — | — | US | disclosed |
| CN-1325480-C | Novel phenylalanine derivatives | AJINOMOTO KK (JP) | 2007-07-11 | — | — | CN | disclosed |
| WO-2007013964-A1 | PYRAZOLO PYRIMIDINES USEFUL AS AURORA KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2007-02-01 | — | — | WO | disclosed |
| US-7153963-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20060223836-A1 | New phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-10-05 | — | — | US | disclosed |
| US-20050101779-A1 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1477482-A1 | NOVEL PHENYLALANINE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2004-11-17 | — | — | EP | disclosed |
| CN-1469867-A | Novel phenylalanine derivatives | ֮����ʽ���� | 2004-01-21 | — | — | CN | disclosed |
| US-20030220268-A1 | New phenylalanine derivatives | AJINOMOTO CO. INC (JP) | 2003-11-27 | — | — | US | disclosed |
| EP-1288205-A1 | NOVEL PHENYLALANINE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223836-A1 | New phenylalanine derivatives | ITGB4, ITGA4, ITGAV | ALDH1A1 1310/4885SMN1; SMN2 1306/4885NPC1 2533/4885 |
| US-20050101779-A1 | Phenylalanine derivatives | ITGB4, ITGA4, ITGB3 | ALDH1A1 987/4885SMN1; SMN2 1611/4885NPC1 1178/4885 |
| US-20110065918-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, ITGA4, ITGAV | ALDH1A1 1310/4885SMN1; SMN2 1306/4885NPC1 2533/4885 |
| US-20030220268-A1 | New phenylalanine derivatives | ITGB4, ITGA4, ITGB3 | ALDH1A1 1237/4885SMN1; SMN2 684/4885NPC1 1766/4885 |
| US-20120253041-A1 | NEW PHENYLALANINE DERIVATIVES | ITGB4, ITGA4, ITGAV | ALDH1A1 1310/4885SMN1; SMN2 1306/4885NPC1 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.