D-Glutamate

D-Glutamate

SCHEMBL910049

NC(CCC(=O)O)C(=O)O.O

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIK1 known ✓ P39086 1/20 0.95
GRIA1 known ✓ P42261 1/20 0.95
GRIA2 known ✓ P42262 1/20 0.95
GRIA3 known ✓ P42263 1/20 0.95
GRIA4 known ✓ P48058 1/20 0.95
GRIN2A known ✓ Q12879 1/20 0.95
GRIK2 known ✓ Q13002 1/20 0.95
GRIK3 known ✓ Q13003 1/20 0.95
GRIK5 known ✓ Q16478 1/20 0.95
GRM8 O00222 2/20 0.95
GRM6 O15303 2/20 0.95
GRM7 Q14831 2/20 0.95
GRM4 Q14833 2/20 0.95
GSR P00390 2/20 0.95
GRIN2D O15399 1/20 0.95
GRIN3B O60391 1/20 0.95
CYP1A2 P05177 1/20 0.95
GRM5 P41594 1/20 0.95
SLC1A3 P43003 1/20 0.95
SLC1A2 P43004 1/20 0.95

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Glutamate SCHEMBL28352293 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
Glutamic Acid SCHEMBL8530554 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
Glutamic Acid SCHEMBL1086195 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
D-Glutamate SCHEMBL5605822 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
D-Glutamate SCHEMBL2880987 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
Glutamic Acid SCHEMBL5605825 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
D-Glutamate SCHEMBL8530551 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
D-Glutamate SCHEMBL5605604 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
Glutamic Acid SCHEMBL5605606 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR
D-Glutamate SCHEMBL28352296 1.00 GRM8 (0.95) GRM8GRM6GRM7GRM4GSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023085645-A1 NOVEL RAMALIN DERIVATIVE AND USE THEREOF FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASES 한국해양과학기술원 2023-05-19 WO claimed
CN-109437341-B Preparation method of metal oxide or composite material thereof, application and battery 深圳先进技术研究院 2020-06-16 CN claimed
US-20120213748-A1 CARDIOMYOCYTES AND METHODS OF PRODUCING AND PURIFYING CARDIOMYOCYTES NISTOR GABRIEL (US) 2012-08-23 US claimed
CN-102098928-A Additive for livestock feed and livestock feed composition AJINOMOTO KK 2011-06-15 CN claimed
CN-101863789-A Method for separation and purification of L-potassium glutamate monohydrate YIXING QIANCHENG BIOLOGY CO LTD 2010-10-20 CN claimed
EP-2139988-A1 CARDIOMYOCYTES AND METHODS OF PRODUCING AND PURIFYING CARDIOMYOCYTES California Stem Cell, Inc. (US) 2010-01-06 EP claimed
WO-2008112323-A1 CARDIOMYOCYTES AND METHODS OF PRODUCING AND PURIFYING CARDIOMYOCYTES CALIFORNIA STEM CELL, INC. (US) 2008-09-18 WO claimed
US-4563359-A MIXTURE OF GLUTAMIC ACID WITH SODIUM AND POTASSIUM SALTS AJINOMOTO COMPANY, LIMITED (JP) 1986-01-07 US claimed
US-4035513-A COSMETICS SHISEIDO CO., LTD. (JA) 1977-07-12 US claimed
CN-116491516-B Emamectin benzoate B2aApplication of salt compound thereof in preparation of medicine for promoting plant growth 河北威远生物化工有限公司 2024-08-30 CN disclosed
CN-116649557-B Microcrystalline monosodium glutamate and preparation method and application thereof 廊坊梅花生物技术开发有限公司 2024-07-16 CN disclosed
WO-2024147332-A1 γ-AMINOBUTYRIC ACID GENERATING COMPOSITION, AND METHOD FOR PRODUCING γ-AMINOBUTYRIC ACID-CONTAINING COMPOSITION 天野エンザイム株式会社 2024-07-11 WO disclosed
CN-118102888-A Method for improving flavor of food 味之素株式会社 2024-05-28 CN disclosed
WO-2024018761-A1 NEUTRAL LIPID AND LIPID NANOPARTICLE 国立大学法人北海道大学 2024-01-25 WO disclosed
US-4988515-A Antiischemic agents THE REGENTS OF THE UNIV. OF CALIF. (US) 1991-01-29 US disclosed
US-4946968-A Method of preparing alkali metal salts of 2-pyrrolidone-5-carboxylic acid DEGUSSA AKTIENGESELLSCHAFT (DE) 1990-08-07 US disclosed
CN-1031025-A NUTRITIVE EMULSION PREPARATION OTSUKA PHARMA CO LTD (JP) 1989-02-15 CN disclosed
EP-0253662-A1 Pharmaceutical compositions ED. GEISTLICH SÖHNE AG FÜR CHEMISCHE INDUSTRIE (CH) 1988-01-20 EP disclosed
US-4514094-A APPARATUS USING ELECTRONIC PROGRAM CONTROL INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1985-04-30 US disclosed
US-4471002-A PHOSPHATES, POTASSIUM AND SODIUM COMPOUNDS, LACTIC ACID INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1984-09-11 US disclosed