Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | BLVRB | P30043 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60154 | 0.89 | NPC1 (0.62) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL59247 | 0.86 | RAB9A (0.72) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL60427 | 0.86 | NPC1 (0.76) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL19154215 | 0.85 | NR1H4 (0.53) | NPC1RAB9ANR1H4CHRNB2CHRNA5 | |
| SCHEMBL17336565 | 0.84 | NPC1 (0.72) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL59426 | 0.83 | NPC1 (0.67) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL60333 | 0.83 | MAOA (0.68) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL5345798 | 0.83 | NPC1 (0.80) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL60606 | 0.83 | NPC1 (0.67) | NPC1RAB9AL3MBTL1MAOABLVRB | |
| SCHEMBL61063 | 0.81 | NPC1 (0.69) | NPC1RAB9AL3MBTL1MAOABLVRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180092887-A1 | COMPOSITIONS OF 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. | 2018-04-05 | — | — | US | disclosed |
| US-8227494-B2 | Pharmaceutical compositions of 1,2,4-oxadiazole benzoic acid and their use for the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8129540-B2 | Methods for the synthesis of 1,2,4-oxadiazole benzoic acid compounds | PTC THERAPEUTICS, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20100168109-A1 | PHARMACEUTICAL COMPOSITIONS OF 1,2,4-OXADIAZOLE BENZOIC ACID AND THEIR USE FOR THE TREATMENT OF DISEASE | PTC THERAPEUTICS, INC. | 2010-07-01 | — | — | US | disclosed |
| US-20100121070-A1 | METHODS FOR THE SYNTHESIS OF 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS | PTC THERAPEUTICS, INC. | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168109-A1 | PHARMACEUTICAL COMPOSITIONS OF 1,2,4-OXADIAZOLE BENZOIC ACID AND THEIR USE FOR THE TREATMENT OF DISEASE | UPF1, RIOX2, PABPC1 | NPC1 448/4885RAB9A 3576/4885L3MBTL1 320/4885 |
| US-20100121070-A1 | METHODS FOR THE SYNTHESIS OF 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS | UPF1, RIOX2, RNMT | NPC1 1403/4885RAB9A 4299/4885L3MBTL1 236/4885 |
| US-20180092887-A1 | COMPOSITIONS OF 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND METHODS FOR THEIR USE | UPF1, RIOX2, RNMT | NPC1 1473/4885RAB9A 4327/4885L3MBTL1 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.