Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9101155 | 0.82 | LMNA (0.65) | LMNATHRBTP53MAPTPOLB | |
| Bepiastine SCHEMBL29560445 | 0.79 | LMNA (0.64) | LMNATHRBTP53MAPTPOLB | |
| Bepiastine SCHEMBL1815039 | 0.79 | LMNA (0.64) | LMNATHRBTP53MAPTPOLB | |
| SCHEMBL14288794 | 0.79 | MAOA (0.64) | LMNAALDH1A1THRBTP53MAPT | |
| SCHEMBL9832554 | 0.73 | MAOA (0.55) | LMNAALDH1A1TP53MAPTPOLB | |
| SCHEMBL8790761 | 0.73 | TTR (0.50) | ALDH1A1HSD17B10 | |
| SCHEMBL9100460 | 0.73 | ALDH1A1 (0.78) | LMNAALDH1A1ALOX15MAPK10HSD17B10 | |
| SCHEMBL11486350 | 0.72 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL5937266 | 0.72 | ALDH1A1 (0.66) | ALDH1A1MAPT | |
| SCHEMBL9178250 | 0.70 | ALDH1A1 (1.00) | LMNAALDH1A1ALOX15MAPK10HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550122-A | INHIBIT REVERSE TRANSCRIPTASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0415303-B1 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMA (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0415303-A2 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-03-06 | — | — | EP | disclosed |